BRCA1,2 gene sequencing – a method to determinate genetic susceptibility to breast and ovarian cancer

17/apr/2019 14:49:24 Isida Clinic Contatta l'autore

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According to the latest research, the BRCA1 and BRCA2 genes are responsible for the occurrence of most types of cancer of mammary gland and ovaries. A genetic test is now available at the ISIDA clinic to determine if the body has mutations in these genes.

 

According to medical statistics, up to 10% of all types of cancer occurs against the background of a genetic mutation that is inherited. Awareness of the presence of mutated genes in the body, which can lead to the occurrence of cancer, allows to take timely action and prevent the development of cancer.

 

With the help of BRCA1,2 gene sequencing, it is possible to exclude or confirm the presence of the BRCA1 and/or BRCA2 gene mutation. Medical statistics show that in the case of mutation, the risk of breast cancer for women by the age of 70 increases to 87%, and for ovarian cancer, to 44%. For comparison: the risk of breast cancer in the general population is 12%, ovarian cancer - 1.3%.

 

The 5 most important facts about the BRCA1 and BRCA2 gene mutations:

 

• The pathogenic mutation in BRCA1 or BRCA2 can be inherited by a child from both the mother and the father. The risk is 50%.

• Mutations in the BRCA1 and BRCA2 genes, in addition to breast and ovarian cancer, increase the risk of fallopian tube and peritoneal cancer.

• BRCA2 gene mutations are dangerous not only for women but also for men. The presence of mutations increases the risk of prostate cancer. In addition, both men and women with pathogenic BRCA1 or BRCA2 mutations have an increased risk of developing pancreatic cancer. Some mutations in BRCA2 (known as FANCD1), if inherited from both parents, can cause a rare form of Fanconi anemia, as well as the development of acute myeloid leukemia. Similarly, some mutations in BRCA1 (known as FCS), if inherited from both parents, can cause another subtype of Fanconi anemia.

• If the genetic analysis shows the presence of a mutation in the BRCA1 or BRCA2 genes, this does not mean that cancer is inevitable. The disease may simply not develop. In addition, modern medicine has quite effective methods to reduce the risk of cancer, even with a positive result for a mutation in the genes.

• To reduce the risk of cancer in the presence of mutations in the genes, modern medicine uses constant monitoring of the state of health, preventive surgical interventions and chemoprophylaxis.

 

How is genetic analysis performed for BRCA1,2 gene mutation

 

To undergo a genetic analysis for the BRCA1,2 genes, you just need to take a blood test. If the test results are positive, your doctor will give you effective recommendations on how to avoid the oncology pathology.

 

ISIDA Clinic has been engaged in the diagnosis and treatment of a whole range of pathologies and diseases for almost 30 years, and every year we gain more experience and knowledge, and our specialists always strive to have the most complete picture possible in order to find the right treatment plan. And here at ISIDA we always achieve high results thanks to the professionalism and diligence of our doctors, and modern technologies. Trust the specialists of ISIDA clinic!

 

Contact us!

Phone: +380 (44) 455 88 14; (044) 490-95-24

Viber: +380 (67) 333 88 14

Skype: ISIDA International

Address: 65, Vatslava Gavela Blvd, Kyiv, Ukraine

https://isida-ivf.com


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